40 percent of MRI signals do not correspond to actual brain activity

Summary

Samira M. Epp, Gabriel Castrillón, Beijia Yuan, Jessica Andrews-Hanna, Christine Preibisch, Valentin Riedl: BOLD signal changes can oppose oxygen metabolism across the human cortex, published in Nature Neuroscience, December 12, 2025, https://doi.org/10.1038/s41593-025-02132-9