Gut Bacteria from Amphibians and Reptiles Achieve Complete Tumor Elimination

Summary

【Key Research Achievements】 Demonstration that natural bacteria isolated from amphibian and reptile intestines achieve complete tumor elimination with single administration Combines direct bacterial killing of cancer cells with immune system activation for comprehensive tumor destruction Outperforms existing chemotherapy and immunotherapy with no adverse effects on normal tissues Expected applications across diverse solid tumor types, opening new avenues for cancer treatment 【Research Overview】 A research team of Prof. Eijiro Miyako at the Japan Advanced Institute of Science and Technology (JAIST) has discovered that the bacterium Ewingella americana, isolated from the intestines of Japanese tree frogs (Dryophytes japonicus), possesses remarkably potent anticancer activity. This groundbreaking research has been published in the international journal Gut Microbes.While the relationship between gut microbiota and cancer has attracted considerable attention in recent years, most approaches have focused on indirect methods such as microbiome modulation or fecal microbiota transplantation. In contrast, this study takes a completely different approach: isolating, culturing, and directly administering individual bacterial strains intravenously to attack tumors--- representing an innovative therapeutic strategy.The research team isolated a total of 45 bacterial strains from the intestines of Japanese tree frogs, Japanese fire belly newts (Cynops pyrrhogaster), and Japanese grass lizards (Takydromus tachydromoides). Through systematic screening, nine strains demonstrated antitumor effects, with E. americana exhibiting the most exceptional therapeutic efficacy. 【Research Details】 Remarkable Therapeutic EfficacyIn a mouse colorectal cancer model, a single intravenous administration of E. americana achieved complete tumor elimination with a 100% complete response (CR) rate. This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune che...